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Abstract

Spectrophotometric Method For The Determination Of Lacidipine In Tablets

Author(s): V Ravichandran, S Raghuraman, V Sankar, V Kalaiselvan, J Dharuman, A Dharamsi

A simple and sensitive spectrophotometric method has been developed for the determination of acidipine in bulk and tablets. The method is based on the reaction of lacidipine with ferric chloride, potassium ferricyanide and hydrochloric acid to form a bluish green colored chromogen with an absorption maximum of 740 nm. Beer's law was obeyed in the range of 0-10 μg/ml. The proposed method has been successfully applied to the analysis of the bulk drug and its dosage forms. Statistical comparison of the result with that obtained with reported method showed good agreement and indicated no significant difference in precision. This method does not require any extraction or heating.