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Abstract

Spectrophotometric method for the determination of nimodipine

Author(s): K. Girish Kumar, K. P. R. Chowdary and G. Devala Rao
Department of Chemistry, Gandhigram Rural Institute, Deemed University, Gandhigram-624 302, Department of Pharmaceutical Sciences, Àndhra University, Visakhapatnam-530 003, Department of Pharmaceutical Analysis and Quality Assurance, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520 010, India

Correspondence Address:
Department of Chemistry, Gandhigram Rural Institute, Deemed University, Gandhigram-624302, E-mail: [email protected]

A simple and sensitive spectrophotometric method for the determination of nimodipine in bulk and pharmaceutical dosage forms is described. The method is based on diazotisation of reduced nimodipine with nitrous acid followed by its coupling with alpha-naphthylamine to form a pink colored chromogen with an absorption maximum of 550 nm. The color obeyed Beer's law in the concentration range of 2-12 mug/ml