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Abstract

Spectrophotometric Method For The Estimation Of Terazosin In Tablets

Author(s): V Sankar, S Raghuraman, V Sivanand, V Ravichandran

A simple and sensitive method has been developed for the estimation of terazosin in tablet formulations. The method is based on diazotisation of primary amine group of terazosin with sodium nitrite and hydrochloric acid followed by coupling with β-naphthol (in alkaline medium) to form a orange red dye, which has the characteristic light absorption in the visible region and having the absorption maximum at 560 nm. So the determination of the drug was based on the absorption at this wave length. Beer's law is obeyed in the concentration range of 1-10 μg/ml. The proposed method is precise, accurate and reproducible and it is extended to the analysis of terazosin in the tablet formulations.