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Abstract

Spectrophotometric Methods For Determination Of Clopidogrel In Tablets

Author(s): P Mishra, Archana Dolly

Two simple, rapid, precise, highly specific and economical spectrophotometric methods have been developed for the determination of clopidogrel bisulphate in its pharmaceutical dosage forms. Method A is based on the reduction of ferric ions to ferrous ions which produce blue colour with potassium ferricyanide with absorption maximum at 760 nm. The chromogen obeyed linearity over 18-32 μg/ml. Method B is based on the hydrolysis of ester linkage of drug into acid form by heating with sulphuric acid. This acid form of drug has absorption maximum at 217 nm. Beer's law is obeyed in the concentration range of 4-18 μg/ml.