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Abstract

Spectrophotometric methods for the determination of dilitiazem in pharmaceutical preparations.

Author(s): YK Agrawal, K Shivramachandra, BE Rao
Department of Chemistry, School of Sciences, Gujrat University, Ahmedbad,

Correspondence Address:
Y K Agrawal Department of Chemistry, School of Sciences, Gujrat University, Ahmedbad

Two spectrophotometric methods for the determination of Diltiazem in Pharmaceutical preparations are described. The methods are based on the formation of coloured complex of the drug with cobalt-thiocyanate and methyl orange. The coloured species were extracted into organic solvents and measured at the wavelengths of maximum absorbance at 630 nm and 420 nm with cobalt and methyl orange respectively. Both the methods shows linearity in the range 60-600 mug/ml and 5-60 mug/ml respectively.