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Abstract

Spectrophotometric Methods For The Determination Of Sibutramine Hydrochloride From Capsules

Author(s): R Valarmathi, S.K.K Sundari, A Puratchikody, Shimi George, S Suresh Kumar, K Ruckmani

A new simple, sensitive spectrophtometric method in ultraviolet region has been developed for the determination of sibutramine hydrochloride in bulk and in capsule dosage form. Sibutramine hydrochloride shows maximum absorbance at 220 nm. Beer's law was obeyed in the concentration range 10-50 μg/ml. Results of the analysis were validated statistically and by recovery studies.