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Abstract

Spectrophotometric Methods For The Determination Of Sparfloxacin In Pharmaceutical Forms

Author(s): K Girish Kumar, K. P. R Chowdary, G Devala Rao

Two simple and sensitive spectrophotometric methods (method A and method B) have been developed for the determination of sparfloxacln in bulkand in pharmaceutical dosage forms. Method A is based on an observation that methanolic solution of sparfloxacin exhibits an absorbance maximum of 295.2 nm and method B Is based on diazotisation of sparfloxacin with nitrous acid followed by its coupling with resorcinol in alkaline medium, to form a colored chromogen with an absorbance maximum of 450 nm. The methods are statistically validated and found to be precise and accurate.