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Abstract

Spectrophotometric methods for the estimation of Cephalexin in tablet dosage forms

Author(s): SA Patel1, NM Patel2, MM Patel1
1Shree S. K. Patel college of Pharmaceutical Education and Research, Ganpat vidyanagar, Kherava, Dist-Mehsana-382 711, India 2B. M. Shah College of Pharmaceutical Education and Research, Modasa-383 315, India

Correspondence Address:
S A Patel Shree S. K. Patel college of Pharmaceutical Education and Research, Ganpat vidyanagar, Kherava, Dist-Mehsana-382 711 India E-mail: [email protected]


Two simple, sensitive, accurate, rapid, and economical spectrophotometric methods, have been developed for the estimation of cephalexin in tablets. Method A is based on the reaction of cephalexin with Folin-Ciocalteu reagent, in presence of 20% sodium carbonate solution, giving a blue colour chromogen, which shows maximum absorbance at 753 nm against reagent blank, while method B is based on the estimation of cephalexin in distilled water, at 263 nm. Beer's law was obeyed in the concentration range of 10-160 µg/ml in method A, and 5-50 µg/ml in method B. Results of the analysis were validated statistically, and by recovery studies.



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