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Abstract

Spectrophotometric Methods For The Estimation Of Ethamsylate In Tablets

Author(s): B.S Kuchekar, V.S Randive, A.P Chaudhari, S.B Bhise

Two simple, accurate, rapid and sensitive methods have been developed for the estimation of ethamsylate in pharmaceutical dosage forms. Method A is based on the reduction of Folin- Ciocalteau phenol reagent by ethamsylate in presence of 20% sodium carbonate solution giving blue chromogen, which shows maximum absorption at 740 nm while method B is based on the reduction of ferric ions (ferric nitrate) to ferrous ions by ethamsylate which then reacts with 1,10-phenanthroline to produce reddish coloured complex showing maximum absorption at 435 nm against reagent blank. In both the methods Beer's law was obeyed in the concentration range of 5-25 μg/ml.