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Abstract

Stability of proteins in aqueous solution and solid state

Author(s): S Jacob, AA Shirwaikar, KK Srinivasan, J Alex, SL Prabu, R Mahalaxmi, Ravi Kumar
Department of Pharmaceutics and Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576104, India

Correspondence Address:
A A Shirwaikar Department of Pharmaceutics and Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576104 India E-mail: [email protected]


In the last two decades, proteins and peptides have become an important class of potent therapeutic drugs. However, their susceptibility to chemical and physical degradation presents a challenge to formulation scientists, for the development of stable pharmaceutical preparations. This is in part, due to the unique physicochemical and biological properties of the proteins and peptide drugs. The insight into the fundamental understanding of the mechanism, by which protein stabilizes, will help in the formulation of protein based pharmaceuticals.



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