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Abstract

Statistical Optimization Supported Product Development Of Anti-Asthmatic Multiparticulate Drug Delivery System

Author(s): S Ray, P. K Ghosh, B Das, L. K Ghosh, B. K Gupta

A multiparticulate drug delivery system of theophylline and etophylline, two widely used anti asthmatic drugs, was developed using factorial design and the manufacturing procedure along with the drug entrapment efficiency of the microcapsules were optimized and suitable statistical models were developed. The release rate and its variation due to addition of film-modifier polyisobutylene were studied. The release was found to follow Higuchi square root kinetics. The developed formulation may be useful in prophylaxis of recurrent and nocturnal asthmatic attacks.