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Abstract

Studies On In Vitro Evaluation Of Some Griseofulvin Tablets

Author(s): Tabitha Ohol, Kamalinder K Singh

Six commercially available brands of Griseofulvin tablets (A to F) available in the Indian market were evaluated for four in vitro parameters such as uniformity of weight, disintegration, dissolution and assay with special emphasis on inter-parmacopoeial difference in dissolution rate profiles. The results of the investigation revealed that although all the brands confirmed to the I. P. specifications of uniformity of weight and distintegration, four brands failed to meet the requirements of the assay. All the brands except one complied with the U. S. P and I. P. dissolution specifications. However, three brands failed to comply with the dissolution specifications of B. P.