Studies On Kinetics Of Drug Release From Modified Guar Gum Hydrophilic Matrices
Guar gum, a naturally occurring galactomannan polysaccharide, has very high intrinsic viscosity and can be used as hydrophilic matrix for controlled release tablets. In the present investigation guar gum has been methylated using sodium hydroxide and dimethylsuphate. Guar gum and methylated guar gum have been evaluated as hydrophilic matrices for controlled release tablets. Effect of the composition of matrices and the method of preparation of tablets on the drug release kinetics from the guar gum and methylated guar gum matrices have been studied and compared.