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Abstract

Studies On Nootropic Activity Of Ramipril And Losartan On Scopolamine-Induced Amnesia In Rats

Author(s): A Annapurna, V Rama Krishna, K Murali Krishna, V Krishna Kumar, K. B Prasad

The present work was carried out to evaluate the effects of angiotensin converting enzyme inhibitor as well as angiotensin receptor antagonist on cognitive functions impaired by scopolamine in rats. In Wistar rats of either sex amnesia was induced by administering scopolamine butyl bromide (2 mg/kg). Ramipril and losartan (1 and 2 mg/kg) were evaluated for their nootropic activity In terms of spatial memory and working memory using Morris water maze task. Ramlpril (1 and 2 mg/kg) and losartan (1 and 2 mg/kg) have shown significant improvement in basal as well as scopolamine-impaired performance with respect to acquisition (P<0.05) and retention of memory (P<0.05) in both spatial and working memory. The observed results suggest that ramipril and losartan improve cognitive function with respect to spatial and working memory processes.