Study Of Antiparkinson's Activity Of Plain And Niosomal Pentoxifylline
The objective of the study was to investigate the antiparkinson's activity of plain and niosomal pentoxifylline. Pentoxifylline was entrapped in niosomes by lipid layer hydration method using Span 60, cholesterol and dicetyl phosphate (10 mg : 10 mg : 2.5 mg). The antiparkinson's activity was investigated on cataleptic score in haloperidol-induced catalepsy model, and locomotor activity in reserpine antagonism and adenosine antagonism at different doses of plain pentoxifylline (40,80 mg/kg) and niosomal pentoxifylline (5,10,15 mg/kg). Plain pentoxifylline (80 mg/kg) and niosomal pentoxifylline (5,10,15 mg/kg) gave significant improvement in haloperidol-induced catalepsy. Plain pentoxifylline (80 mg/kg) and niosornal pentoxifylline (10, 15 mg/kg) showed significant increase in locomotor avtivity of reserpinetreated mice and adenosine-treated rats. Results suggest that pentoxifyl!ine may prove to be an effective drug in Parkinson's treatment as an adjuvant.