Supercritical Fluid Extraction And Chromatography Of Misoprostol From Tablets
A binary mixture of supercritical carbon dioxide and 5% methanol has been used for the supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC) of misoprostol from methanolic solutions. The pressure, temperature and mobile phase parameters were evaluated for both SFE and SFC. The optimum parameters for SFE and SFC have been cited and the data is evaluated statistically. The method was successfully employed for the SFE/SFC of misoprostol from tablet formulations dispersed in hydroxy propyl methyl cellulose.