Sustained ophthalmic delivery of gatifloxacin from In situ gelling system
Department of Pharmaceutics, K.L.E.S's College of Pharmacy, J. N. M. C. Campus, Nehru Nagar, Belgaum - 590 010, India
R C Doijad Department of Pharmaceutics, K.L.E.S's College of Pharmacy, J. N. M. C. Campus, Nehru Nagar, Belgaum - 590 010 India E-mail: [email protected]
The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of drug may be overcome by the use of in situ gel-forming systems that are instilled as drops into the eye and undergo a sol-gel transition in the cul-de-sac. The present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent, gatifloxacin, based on the concept of ion-activated systems. Sodium alginate was used as the gelling agent in combination with hydroxy propyl methyl cellulose (Methocel E50LV), which acted as a viscosity enhancing agent. The developed formulations were therapeutically efficacious, stable, non-irritant and provided sustained release of the drug over an eight hour period. The developed system is thus a viable alternative to conventional eye drops.