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Abstract

Synthesis and antibacterial activity of 7-ethoxy-4-(substituted)-aminomethylcoumarins.

Author(s): M Nagesam, KM Raju, MS Raju
Dept. of Chemistry, Sri Krishnadevarayya University, Anantapur-515 003,

Correspondence Address:
M Nagesam Dept. of Chemistry, Sri Krishnadevarayya University, Anantapur-515 003

A series of 7-ethoxy-4-substituted aminomethylcoumarins have been synthesised making use of the selective reactivity of methyl and formyl groups in position-4 of coumarin nucleus. All these compounds have been screened for their antibacterial activity. Compounds with anilinomethyl, picolinylaminomethyl function in position-4 of coumarin ring system showed higher inhibition of bacterial growth. The other compounds showed only moderate activity.