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Abstract

Synthesis And Antibacterial Activity Of Mannich Bases Of Ciprofloxacin And Lomefloxacin With Isatin And Its Derivative

Author(s): S. N Pandeya, C Gnana Sundari, N Mariammal, P Saravanan, S Saravana Balaji, R Sentil Kumar, D Sriram

Mannich bases of ciprofloxacin and lomefloxacin with isatin and its derivative were synthesized by condensing acidic 'NH' group of isatin with formaldehyde and the secondary amino group (piperazine moiety) of ciprofloxacin and lomefloxacin and screened for antibacterial activity. Mannich bases of ciprofloxacin are equipotent or more potent than cirprofloxacin against certain pathogenic microorganisms. Mannich bases of lomefloxacin are equipotent to that of lomefloxacin.