Synthesis and antibacterial activity of triphenyltinbenzoate
Department of Pharmaceutical Chemistry, School of Pharmacy, Addis Ababa University, Addis Ababa, PO Box 1176, Ethiopia
E-mail: [email protected]
Triphenyltinbenzoate was synthesized using triphenyltinchloride and silver benzoate prepared from sodium benzoate. The structure of the synthetic compound was elucidated by spectral and C, H analysis. The antibacterial activities of the organotin compound were determined against four bacteria namely Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923), Streptococcus pyogenes (clinical isolate) and Pseudomonas aeruginosa (ATCC 27853) in vitro experiment. All the bacteria were inhibited at a concentration of 200 ?g/ml and 20 ?g/ml in dimethylsulphoxide solution and the minimum inhibitory concentration was found to be same, 7.5 ?g/ml for Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes and 10 ?g/ml for Pseudomonas aeruginosa.