All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis and anticonvulsant activity of a new series of 1,4-dihydropyridine derivatives

Author(s): R Surendra Kumar1, A Idhayadhulla1, A Jamal Abdul Nasser1, S Kavimani2, S Indumathy2
1 P. G. and Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli - 620 020, India 2 Department of Pharmacology, Mother Theresa Post Graduate and Research Institute of Health Science, Puducherry - 605 006, India

Correspondence Address:
A Jamal Abdul Nasser P. G. and Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli - 620 020 India E-mail: [email protected]


A series of 1,4-dihydropyridine derivatives (1a-g) were prepared from three compounds condensation of Hantzsch synthesis. A new series of 2,2'-{[4-(aryl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazinecarbothioamide (2a-g) were prepared from compounds diethyl 4-(aryl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1a-g) reacted with thiosemicarbazide to give the corresponding compounds (2a-g) by hydrazinolysis method. The synthesized compounds were confirmed by IR, 1HNMR, 13CNMR, mass spectral and elemental analyses. The newly synthesized compounds (2a-g) were screened for anticonvulsant activity against in swiss albino rat. The test was evaluated by maximal electrode induced convulsion method. Synthesized compounds were used two (50 and 100 mg/kg) concentrations. Compounds (1a-g) were inactive while compounds (2a-g) have moderate anti-convulsant activity compared with standard phenytoin drug. The compound 2,2'-{[4-(furan-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl} dihydrazinecarbothioamide (2a) has highly active compared with other compound (2b-2g).



Share this