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Abstract

Synthesis And Antiinflammatory Activity Of Aryl Sulphonanilides Structurally Related To Nimesulide

Author(s): Vinayata Attal, D.P Belsare

Substituted sulphonanilides of diphenyl ether, benzyl phenyl ether and diphenylamine were synthesized which were structurally related to antiinflammatory drug nimesulide. Synthesized compounds displayed antiinflammatory activity comparable with that of nimesulide. From the result it can be concluded that the replacement of methane sulphonanilide group with other sulphonanilide and replacement of ether oxygen with -OCH2-,-NH- decreases activity.