All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis and antiinflammatory activity of newer pyrazolinylbenzidines and isoxazolinylbenzidines

Author(s): S Sharma1, KK Saxena2
1Department of Chemistry, ITM University Gwalior, NH-75, Gwalior-475 001, India 2Department of Pharmacology, Lala Lajpat Rai Memorial Medical College, Meerut-250 004, India

Correspondence Address:
S Sharma Department of Chemistry, ITM University Gwalior, NH-75, Gwalior-475 001 India E-mail: [email protected]


In an effort to search for more active antiinflammatory agent, a series of pyrazolinylbenzidines and isoxazolylbenzidines was designed, synthesized, and screened for their potential as novel orally inflammation inhibitors. Compounds 4,4'-bis-(1''-acetyl-5''-substitutedaryl-2''-pyrazolin-3''-yl)benzidines (8-13) and 4,4'-bis-(2''-substitutedaryl-isoxazolin-4'-yl)benzidines (14-19) have been synthesized from 4,4'-bis-(substituted benzylidenyl-acetyl)benzidines (2-7). The structures of the products have been delineated by spectral and elemental analysis. Compounds 2-19 evaluated for antiinflammatory activity and acute toxicity and results are reported. The compound 4,4'-bis-[1''-acetyl-5''-(p-methoxyphenyl)-2''-pyrazolin-3'-yl)benzidine (9) showed more potent and dose-dependent antiinflammatory activity in comparison to reference drug.



Share this