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Abstract

Synthesis And Antiinflammatory Activity Of Oleanolic Acid Hemiphthalate Disodium Salt

Author(s): Yuling Fan, Fude Cui, Peigang Yan, Qingpo Li

A simple method for synthesis of oleanolic acid hemiphthalate disodium salt has been successfully, developed. The structures of the newly synthesized compounds were elucidated on the basis of analytical and spectral data. The antiinflammatory activity of oleanolic acid hemiphthalate disodium salt was performed on dimethyl benzene-induced acute ear oedema model. In the acute inflammatory model, oleanolic acid hemiphthalate disodium salt exhibited significant antiinflammatory activity with single and multiple doses with no matter oral, or subcutaneous or intraperitoneal administration. Furthermore antiinflammatory activity of oleanolic acid hemiphthalate disodium salt was better than oleanolic acid with single dose with various administration methods and with multiple doses with oral administration method.