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Abstract

Synthesis and antimicrobial activity of novel 2-Methyl-3-(1'3'4'-Thiadiazoyl)-4-(3h) Quinazolinones

Author(s): Varsha Jatav, SK Jain, SK Kashaw, P Mishra
Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470 003, India

Correspondence Address:
P Mishra Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470 003, India E-mail: [email protected]


With a view to explore the versatile lead molecule 4(3H)-quinazolinones, a series of novel 2-methyl-3-(1'3'4'-thiadiazoyl)-4-(3H) quinazolinones have been synthesised by reacting 2-amino-5-aryl/alkyl-1'3'4'-thiadiazoyl with 2-substituted benzoxazin-2-one. The designed compounds (5a-f) were screened in vitro for antibacterial activity on Staphylococcus aureus , Bacillus subtilis , and Escherichia coli . Antifungal activity was screened against Candida albicans , Aspergillus niger , and Curvularia lunata . Synthesised compounds exhibited both antibacterial and antifungal activity.



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