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Abstract

Synthesis And Antimicrobial Evaluation Of 5-Oxoimidazolylaminopyrazole-4-Carboxaldehydes And Their Schiff's Bases

Author(s): Biplab De, G. V. S Rama Sarma

Condensation of 1-amino-4-benzylidene-2-methyl/phenylimidazolin-5 (4H)-ones (1&2) with 5-chloro- 3-methyl-1-substituted pyrazole-4-carboxaldehydes (3&4) gave corresponding 5-(4-benzylidene-2- methyvphenyl-5-oxoimidazolin -1-yl) amino -3-methyl-1-substituted pyrazole-4-carboxaldehydes (5-8). These were reacted with arylamines to afford corresponding Schiff's bases (9-20). All these compounds were characterized and evaluated for their antibacterial and antifungal activities. Some of them were found to exhibit significant antibacterial and antifungal activities.