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Abstract

Synthesis And Antimicrobial Evaluation Of Some Novel Organometallic Compounds Against Helicobacter Pylori

Author(s): A. R Shaikh, V. S Velingkar, V. S Borkar

Some novel organometallic compounds were prepared by complexing the antibiotics, tetracycline, azithromycin, cefotaxime, cephalexine, and antibacterials, ofloxacin, norfloxacin and gatifloxacin with bismuth citrate. They were characterized by UV, IR, NMR and elemental analysis-Their antibacterial activity against Helicobacter pylori and other microorganisms was investigated. Tetracycline- bismuth citrate was found to possess strong activity against H. pylori with a lowest inhibitory concentration of 125 mg/l. These complexes exhibited moderate activity against Escherichia coli, Klebsiella pneumoniae, Bacillus pumilis, Staphylococcus aureus and Candida albicans. The findings suggest that the activity of these organometallic compounds might be specifically directed agafhst H. pylori.