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Abstract

Synthesis And Antimicrobial Screening Of Novel Mannich Bases Of Isatin Derivative

Author(s): S. A Khan, N Siddiqui, M Imran, S. W Haque

A new series of N-Mannich bases (la-lh) of 3-semicarbazino isatin (I) was synthesized by reacting (I) with formaldehyde and various aromatic primary amines. The chemical structures were confirmed by means of IR, 1H NMR and elemental analysis. The compound; synthesized were screened for antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans by cup plate method. All the compounds showed remarkable antimicrobial activity except compound If that showed moderate activity against S. aureus.