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Abstract
Synthesis and biological evaluation of some novel quinazolones
Author(s): EM Jessy, A Thirugnana Sambanthan, J Alex, CH Sridevi, KK Srinivasan
Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka - 576 104, India
Correspondence Address:
E M Jessy Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka - 576 104 India E-mail: jessyjamesmathew@yahoo.co.in
Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka - 576 104, India
Correspondence Address:
E M Jessy Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka - 576 104 India E-mail: jessyjamesmathew@yahoo.co.in
In view of the potent antimicrobial and antiinflammatory activities exhibited by quinazolin-4-(3H)-ones, a series of novel 2, 3-disubstituted-3,1-quinazolin-4-(3H) ones have been synthesized. The synthesized compounds were screened for antibacterial and antiinflammatory activities. Compounds 3a and 3l showed significant antiinflammatory activity comparable to ibuprofen, while the compound 3J showed antibacterial activity comparable to ciprofloxacin.
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