Synthesis and Cytotoxic Studies of Undecenoic Acid-based Schiffs Base Derivatives Bearing 1,2,4-Triazole Moiety
Centre for Lipid Research, 1Chemical Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500 007, 2Raja Bahadur Venkata Rama Reddy Women's College, Narayanguda, Hyderabad-500 029, 3Academy of Scientific and Innovative Research, Ghaziabad-201 002, India
Academy of Scientific and Innovative Research, Ghaziabad-201 002, India, E-mail: [email protected]
A series of novel 1,2,4-triazole-based schiff’s base derivatives were synthesized by condensing undecenoic triazole compound with various substituted benzaldehydes. Compounds so synthesized were thoroughly characterized using 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, high resolution mass spectrometry and Fourier transform-infrared spectroscopy. Cytotoxicity of these compounds was tested in vitro on three cancer cell lines, B16 F10 (mouse melanoma cancer cells), HCT-15 (human colon cancer cells), SKOV3 (human ovarian cancer cell line) and NIH-3T3 (normal mouse embryonic fibroblasts) using MTT assay. The results showed that most of the compounds exhibited cytotoxicity against the tested cell lines. Among the tested compounds, 6g and 6n showed significant cytotoxicity against B16 F10 cells and compounds 6i, 6n, 6o, 6p and 6q against HCT-15 cell line. The schiff’s base derivative 6g, appeared to be the most effective on B16 F10 cancer cells due to bromo substitution on the 4th position of the phenyl ring. Altogether, the cytotoxicity of these compounds observed against cancer cells indicate anticancer potential.