Synthesis And Evaluation Of 1-Aryl-4-N-Arylamino-2-Phenyl-4-Thiomethyl-1,3-Diazabuta-1,3-Dienes : A Novel Class Of Antibacterial Agents
Several N -arylamino-1,3-diazabuta-1,3-dienes were prepared by the reaction of N-arylbenzimidoyl isothiocyanates with primary aromatic amines followed by S-methytation of the resultant thioureas. All these compounds were characterised by analytical and spectral data. Antibacterial activity was determined using agar diffusion technique against Escherichia coli MTCC 42, Pseudomonas aeruginosa MTCC 1034, Bacillus subtilis MTCC 121, Bacillus cerus MTCC 1272 and Staphylococcus aureus MTCC 1430. Some of the compounds showed significant antibacterial activity.