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Abstract

Synthesis And Evaluation Of New 4-Aryl/Heteroaryl-2, 6-Dimethyl-3, 5-Bis-N-(Arylcarbamoyl)-1, 4-Dihydropyridines As Pharmacodynamic Agents - Part-I

Author(s): S. K Swamy, T. M Reddy, V. M Reddy

Seven new 4-aryl/heteroaryl-2,6-dimethyl-3,5-bis-N-(2-methyl phenyl) carbamoyl-1, 4-dihydropyridines were prepared through one-pot synthesis starting from (2-methylphenyl) acetoacetamide using appropriate aromatic aldehydes and liquid ammonia. These compounds were purified and characterized by their analytical and spectral data. Pharmacological screening of the new 1,4-dihydropyridines was carried out for CNS depresant (anticonvulsant and analgesic) and cardiovascular (inotropic and blood pressure) activities by standard methods. Quite a few of them were found to be active.