Synthesis and evaluation of novel benzothiazole derivatives against human cervical cancer cell lines
Dept. of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576 104, India
Suvarna Kini Dept. of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576 104 India E-mail: [email protected]
The 2-arylsubstituted benzothiazole derivatives were synthesized by refluxing o-aminothiophenol with substituted benzoic acids in the presence of polyphosphoric acid at 220°. 2-Mercaptothiazole was used along with thionyl chloride to get the carbothioates. The physical and spectral data such as mp, Rf, IR, NMR was obtained for the synthesized compounds and the structures were confirmed. The screening for antitumour activity was done as per the National Cancer Institute drug screening strategy 3 compounds were found to be significantly cytotoxic as compared to [2-(3-bromo-4-aminophenyl) benzothiazole] against the human cervical cancer cell lines.