All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis and in vitro screening of 29, 30-dibromo-28-oxoallobetulin against parasitic protozoans, leishmania donovani and leishmania major

Author(s): P Ghosh1, A Mandal1, S Dey2, C Pal2
1Natural Products and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Raja Rammhunpur, Darjeeling-734 013, India 2Cellular Immunology and Experimental Therapeutics Laboratory, Department of Zoology, West Bengal State University, Barasat-700 126, India

Correspondence Address:
P Ghosh Natural Products and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Raja Rammhunpur, Darjeeling-734 013 India E-mail: [email protected]


A simple synthesis and in vitro antileishmanial activity of 29,30-dibromo-28-oxoallobetulin against the parasitic protozoans, Leishmania donovani and Leishmania major is described. The structure of the compound is established on the basis of spectral data (IR, NMR, MS). Both the antiproliferative effect and the cell cycle progression were studied.



Share this