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Abstract

Synthesis and invitro amoebicidal activity of some n,n'-disubstituted diamine dihydrochlorides.

Author(s): PL Kachroo, R Gupta, R Wadhwan
DEpt. of Chemistry, University, of Jammu, Jammu-180 001,

Correspondence Address:
P L Kachroo

Sixteen N'-alkyl and N'-aryl-N-[3-(2, 4-dialkoxy-5-alkylphenyl) propyl]-1, 2- diaminoethanes (IV) have been synthesised by treatment of 2,4-dialkoxy-5-alkylbenzene-propanoylchlorides with glycine followed by conversion of the resultant acids (III) into acid chlorides; condensation of acid chlorides with amines and LAH reduction of resultant diamides. The diamines isolated as dihydrochlorides have been tested in vitro for amoebicidal activity against E. histolytica.