Abstract

Synthesis and pharmacology of substituted naphthalenes part-I : methyl 1-acetoxy-3-nephthoates.

Author(s): SG Kashediker, G Bagavant
Department of Pharmaceutical Sciences, Nagpur University, Nagpur-440 010,

Correspondence Address:
S G Kashediker Department of Pharmaceutical Sciences, Nagpur University, Nagpur-440 010

Substituted methyl 1-acetoxy-3-napthoates were prepared. They were evaluated for antiinflammatory, analgesic and antipyretic properties, several of them showed statistically significant activities compared to standard NSAIDS. The ED50 and LD50 of the two most active compounds showed them to be potentially therapeutically useful.