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Abstract

Synthesis and study of n-(2-mercapto-4,5-disubstituted phenyl)-n'-substituted-phenyl thioureas as possible antituberculosis agents.

Author(s): SM Patil, VG Shirke, VR Lokhande, AS Bobade, BG Khadse
Dept. of Chemotherapy, Haffkine Institute, Parel, Bombay-12

Correspondence Address:
S M Patil Dept. of Chemotherapy, Haffkine Institute, Parel, Bombay-12

A series of N-(2-mercapto-4,5-disubstituted-phenyl)-N'-substituted phenyl thioureas have been synthesized and screened in vitro against H37 Rv strain of Mycobacteriumtuberculosis. The antitubercular activity of these compounds vary from 50 mug/ml to 0.6 mug/ml.