Synthesis, anticonvulsant, antimicrobial and analgesic activity of novel 1,2,4-dithiazoles
Department of Pharmaceutical Sciences, Pharmaceutical Chemistry Division, Dr. H. S. G our University, Sagar-470 003, India
S K Kashaw Department of Pharmaceutical Sciences, Pharmaceutical Chemistry Division, Dr. H. S. Gour University, Sagar-470 003 India E-mail: [email protected]
A series of 1,2,4-dithiazole were synthesized from 1,2,4-thiadiazoles in the presence of CS 2 and evaluated for their antimicrobial, anticonvulsant, analgesic and neurotoxicity potential. The compounds provided significant protection against maximal electroshock-induced seizures and seizures induced by 300 mg/kg of subcutaneous pentylenetetrazole administration. The designed compounds (3a-g) were screened in vitro for antibacterial activity against Staphylococcus aureus Escherichia coli , Bacillus subtilis and Pseudomonas aeruginosa and antifungal activity in fungal strains of Candida albicans and Aspergillus niger. Synthesized compounds exhibited moderate antibacterial and antifungal activity. N,N -Di-naphthalen-1-yl- N -(thioxo-5 H -[1,2,4]dithiazol-3-yl)-guanidine and N,N -Bis-(4-fluoro-phenyl)- N -(5-thioxo-5 H -[1,2,4]dithiazol-3-yl)-guanidine showed analgesic activity by tail flick method.