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Abstract

Synthesis, Characterization and DPPH Scavenging Assay of Isatin Related Spiroheterocyclic Compounds

Author(s): M. Nagoor Meeran* and A. Z. Hussain
Department of Chemistry, Vivekanandha College of Arts and Sciences for Women, Tiruchengode-637 303, PG and Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli-620 020, India

Correspondence Address:
Department of Chemistry, Vivekanandha College of Arts and Sciences for Women, Tiruchengode-637 303, India, E-mail: [email protected]


Isatin is synthetically a versatile substrate that can be used for the synthesis of large variety of heterocyclic compounds. 5-substituted isatins were treated with 2-amino-5-chlorobenzo phenone to form Schiff’s bases. Spirothiozolidin-4-ones and 5’-methyl-spiro-4-thiazolidiones were synthesized Schiff’s bases of isatins by treating with thioglycolic acid and thiolactic acid, respectively in the presence of 1,4-dioxane and anhydrous zinc chloride. The structures of the synthesized compounds were characterized by elemental and spectral analysis. These compounds were screened for their antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl method. Compound A02 found to possess potent antioxidant activity compared to the standards ascorbic acid and butylated hydroxytoluene.



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