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Abstract

Synthesis of 1-deoxy-1-[(4-quinazolon-3-yl) amino/methyl-amino-d-fructose as cns active compounds.

Author(s): SR Nautiyal, VR Agarwal, DD Mukerji
Dept. of Chemistry, University of Lucknow, Lucknow 226 007,

Correspondence Address:
S R Nautiyal Dept. of Chemistry, University of Lucknow, Lucknow 226 007

A new series of 4-quinazolone i.e. 1-deoxy-1-(alpha-substituted-3-amino/methylamino-4-quinazolono)-D-fruc tose have been synthesized by refluxing oxalate salt of 3-amino-4-quinazolone and anhydrous D-glucose, with a view to observe the effect of aldose and amines linkage on central nervous system. The compounds were tested on albino mice of both sex. Some of them showed CNS depressant effect.