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Abstract

Synthesis of new 4-arylazo-1-(5-substituted benzoxazolin-2, oxyacetyl)-3-methyl-pyrazolin-5-ones and their evaluation as antiviral agents

Author(s): VS Misra, S Sen, N Srivastava, HN Verma, M MA Khan, SK Khan
Chemistry Dept. & Plant Virus Laboratory, Lucknow University, Lucknow-226 007

Correspondence Address:
V S Misra Chemistry Dept. & Plant Virus Laboratory, Lucknow University, Lucknow-226 007

A series of 4-arylazo-1-(5-substituted benzoxazolin-2'-oxyacetyl)-3-methyl pyrazolin-5-ones (1-20) have been synthesised and evaluated for their action against Ranikhet Disease, Sunnhemp Rosette, and Cucumber Green Mottle Mosaic viruses. None of the compounds inhibited SRV and CGMMV significantly. However, compounds 3 and 10 showed significant activityy against RDV and inhibited the viral growth upto 72 percent