All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis Of New 4-Thiazolidinones And 2-Azitidiones With Their In Vitro Biological Activities

Author(s): Mazaahir Kidwai, Renu Bala, Kaushlendra Kumar

A series of 2-aryl-3-[(3'5'-dinitrobenzamido)]-thiazolidin-4-ones and N-[3'5'-dinitrobenzamido]-3-chloro-4-(aryl substituted) azetidin-2-ones have been prepared and examined for antibacterial and antifungal activity in vitro against E.coli (gram negative), S. aurus (gram positive) and A.niger, A. flavous respectively. The reaction of 3,5-dinitrobenzoic acid with thienyl chloride in the presence of dry methanol yields 3,5-dinitro-benzoate, on condensation with various aromatic aldehyde gave 2-(3'5'- dinitrobenzoyl) hydrazones, which on cycle-addition with thioglycollic acid and chloracetyl chloride gave 2-aryl-3-[(3'5'-dinitrobenzamido)]-thiazolidin-4-ones and N-[3,5,- dinitrobenzamido] -3-chloro-4-(aryl substituted)-azetidine-2-ones respectively.