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Abstract

Synthesis of n-isonicotinoyl flavanone hydrazones as possible antibacterial and antitubercular agents

Author(s): A Shivhare, AV Kale, DD Berge, HP Gupta
Dept. of Chemistry, P.G. College, Ambah 476 111

Correspondence Address:
A Shivhare Dept. of Chemistry, P.G. College, Ambah 476 111

Some N-isonicotinoyl flavanone hydrazones (IIIa-f) have been synthesized by condensing isonicotinic acid hydrazide (INH,II) with suitably substituted chalcones (Ia-f) at pH 4.2 (approx). The compounds when screened in-vitro, exhibited recordable antitubercular activity.