All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis Of Propafenone, An Antiarrhythmic Agent

Author(s): V. D Patil, C. L Viswanathan

Propafenone, an antiarrhythmic agent belonging to class I C was synthesized by two different methods starting from phenol. Method-1 involving initial formation of chalcone from o- hydroxyacetophenone was superior over methods-2 with respect to yield and reaction process. In method-2, the oxypropanolamine chain was built and then aldol condensation was carried out.