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Abstract

Systemic Delivery Of Genetic Material By Non-Viral Vectors

Author(s): P Tyagi, J Ali, Alka Ahuja, Sanjula Baboota, R. K Khar

This article introduces the reader to a number of ventures incorporated in the field of non-viral gene delivery and also the applications of these vectors in the field of gene therapy. The near completion of human genome project has led scientists to search for novel techniques to deliver the newly found genes, which in turn are responsible for a disease. Vehicles for gene delivery in vivo can be divided into viral and non-viral vectors. Non-viral gene delivery involving the use of cationic lipids and polymers still continues to enjoy a high profile due to the safety and advantages offered by these systems when compared to viruses. The clinical use of non-viral gene delivery systems in cystic fibrosis or cancer has involved their direct application to the site of pathology due to targeting difficulties experienced.