The Effects of Gender and Multiple Oral Dosing on the Pharmacokinetics and Bioavailability of Morroniside in Beagle Dogs: A Pilot Study
Institute of Materia Medica, Shandong Academy of Medical Sciences, Ji'nan, Key Laboratory of Drug Metabolism and Pharmacokinetics, Beijing Institute of Pharmacology and Toxicology, Beijing, Department of pharmacy, Guangzhou Hui-Ai Hospital, Guangzhou, China
Key Laboratory of Drug Metabolism and Pharmacokinetics, Beijing Institute of Pharmacology and Toxicology, Beijing, China E-mail: [email protected]
Morroniside is a well-known iridoid plant glycoside. Attempts were made to study the effects of gender and multiple oral dosing on the pharmacokinetics and bioavailability of morroniside in beagle dogs. The concentration of morroniside in plasma was determined using a LC-MS/MS method. Main pharmacokinetic parameters were estimated by DAS 2.0 pharmacokinetic software. Statistical analysis was performed using student t-test with P-values less than 0.05 as the level of significance. No significant gender difference was observed in the pharmacokinetic behaviour of morroniside and no differences were observed in the pharmacokinetic parameters following single and multiple administrations of morroniside. The absolute bioavailability after the oral administration of morroniside in beagle dogs was found to be 7.47±0.65%.