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Abstract

The Multifaceted Profile Of Cox-2 Enzyme And Emerging Therapeutic Uses Of Cox-2 Inhibitors

Author(s): Hetal B Prajapati, Rajani Giridhar, M.R Yadav

The enzyme, cyclooxygenase is now well recognized to exist in two isoforms i.e. cyclooxygenase-1 and cyclooxygenase-2. Cyclooxygenase-1 is constitutively expressed serving the so-called 'house-keeping' role while, cyclooxygenase-2 was thought to be expressed in pathophysiological conditions such as inflammation. It is now known that cyclooxygenase-2 plays a key role in a wide range of physiological processes. In the current article the multifaceted profile of cyclooxygenase-2 enzyme in th'e body is described indicating its potential clinical and diagnostic applications. It is also discussed how the currently available selective cyclooxygenase-2 inhibitors can affect the normal physiological role of cyclooxygenase-2 enzyme.