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Abstract

The Structure And Function Of Systemic Circulatory Lipoproteins And Their Influence On Drug Disposition And Pharmacological Activity

Author(s): Kishor M Wasan, Manisha Ramaswamy, Ramaswamy Subramanian

Lipoproteins are particles of lipids and proteins that primarily transport lipids through the vascular and extravascular body fluids to cells that require them for energy purposes. However, recent evidence has suggested that lipoproteins may act as transporters of different drug compounds and this interaction could lead to alterations in the biopharmaceutical and pharmacological action of the drug. In this paper, the important aspects of lipoprotein structure and function are discussed. Furthermore, the role of lipoproteins as transporters of hydrophobic drug compounds within the systemic circulation and the factors that influence the interaction with lipoproteins will be reviewed.