Therapeutic Efficacy Of Medicinal Plants Against Experimentally Induced Shigellosis In Guinea Pigs
The therapeutic efficacy of higher plants viz. Camellia sinensis L. (Theaceae) and Chamaesyce hirta Millsp. (Euphorbiaceae) was studied against experimentally-induced shigellosis in guinea pigs. The aqueous extract of black tea, polyphenon 60 (mixture of catechins), quercetrin (flavonoid glycoside) and quercetin (aglycone of quercetrin), the two latter compounds being obtained from Chamaesyce hirta showed promising in vitro antibacterial activity against Shigella flexneri 2452 and when tested in the in vivo model of experimental shigellosis, all of them completely cured the guinea pigs within three days. In the untreated group, all the guinea pigs died within 24 h.