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Abstract

Twice a day ocular inserts of acyclovir by melt extrusion technique

Author(s): SP Jain, Sejal Shah, Namita Rajadhyaksha, PP Singh, Purnima Amin
Pharmaceutical Sciences and Technology Division, Institute of Chemical Technology, University of Mumbai, Matunga, Mumbai - 400 019, India

Correspondence Address:
Purnima Amin Pharmaceutical Sciences and Technology Division, Institute of Chemical Technology, University of Mumbai, Matunga, Mumbai - 400 019 India E-mail: [email protected]


Acyclovir, an antiviral is used in the treatment of ocular infections. Acyclovir is effective against human herpes viruses including Herpes simplex virus type 1 and 2, Varicella Zoster virus, Epstein-Barr virus and Cytomegalovirus. Acyclovir is available as a 3%w/w eye ointment to be applied 5 times a day in the eye. The present investigation was aimed at designing a twice a day ocular inserts of acyclovir by melt extrusion technique to improve patient compliance, using hydroxypropylcellulose as a thermoplastic polymer. Also, the developed formulation would overcome the greasy nature of the eye ointment. The developed inserts were stable, non-irritant and provided release of the drug over a period of 10 hours in vitro .



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